化学
炔丙基
镁
催化作用
烯烃纤维
溴化镁
有机化学
氯化物
溶剂
炔丙基溴
溴化物
药物化学
作者
Hassane Faraj,André Aumelas,M. Claire,Anne Rondot,Gilles Auzou
出处
期刊:Steroids
[Elsevier]
日期:1991-11-01
卷期号:56 (11): 558-561
被引量:9
标识
DOI:10.1016/0039-128x(91)90013-l
摘要
As part of continuing studies on the synthesis of new, biologically interesting 11 beta-substituted steroidal spirolactones, we describe here the competition between 10 beta-propargylation and 11 beta-allenylation. Grignard addition of allenyl magnesium bromide to an appropriate 5,10-epoxy-9(11)-olefin provides 10 beta-propargylation or 11 beta-allenylation. The role of the catalytic effect of copper chloride and of the solvent is evaluated. Confirmation of the structural assignments of these new 3,3-ethylenethioxy-10 beta-propargyl (or 11 beta-allenyl)-19-nor-17 alpha-pregna-4,9-diene-21,17-carbolactones is reported.
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