微泡
生物
细胞生物学
外体
刺猬
Wnt信号通路
生物发生
信号
刺猬信号通路
细胞外基质
信号转导
细胞信号
细胞外
小RNA
遗传学
基因
作者
Ian J. McGough,Jean‐Paul Vincent
出处
期刊:Development
[The Company of Biologists]
日期:2016-07-15
卷期号:143 (14): 2482-2493
被引量:155
摘要
In order to achieve coordinated growth and patterning during development, cells must communicate with one another, sending and receiving signals that regulate their activities. Such developmental signals can be soluble, bound to the extracellular matrix, or tethered to the surface of adjacent cells. Cells can also signal by releasing exosomes - extracellular vesicles containing bioactive molecules such as RNA, DNA and enzymes. Recent work has suggested that exosomes can also carry signalling proteins, including ligands of the Notch receptor and secreted proteins of the Hedgehog and WNT families. Here, we describe the various types of exosomes and their biogenesis. We then survey the experimental strategies used so far to interfere with exosome formation and critically assess the role of exosomes in developmental signalling.
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