数量性状位点
生物
候选基因
遗传学
基因座(遗传学)
单核苷酸多态性
遗传建筑学
表型
全基因组关联研究
微卫星
基因
等位基因
遗传标记
基因型
作者
I. C. Cho,H. B. Park,Chae-Kyoung Yoo,G. J. Lee,Hyun‐Tae Lim,J. B. Lee,Eun Ji Jung,Moon-Suck Ko,J. H. Lee,J. T. Jeon
标识
DOI:10.1111/j.1365-2052.2011.02204.x
摘要
Haematological traits play important roles in disease resistance and defence functions. The objective of this study was to locate quantitative trait loci (QTL) and the associated positional candidate genes influencing haematological traits in an F2 intercross between Landrace and Korean native pigs. Eight blood-related traits (six erythrocyte traits, one leucocyte trait and one platelet trait) were measured in 816 F2 progeny. All experimental animals were genotyped with 173 informative microsatellite markers located throughout the pig genome. We report that nine chromosomes harboured QTL for the baseline blood parameters: genomic regions on SSC 1, 4, 5, 6, 8, 9, 11, 13 and 17. Eight of twenty identified QTL reached genome-wide significance. In addition, we evaluated the KIT locus, an obvious candidate gene locus affecting variation in blood-related traits. Using dense single nucleotide polymorphism marker data on SSC 8 and the marker-assisted association test, the strong association of the KIT locus with blood phenotypes was confirmed. In conclusion, our study identified both previously reported and novel QTL affecting baseline haematological parameters in pigs. Additionally, the positional candidate genes identified here could play an important role in elucidating the genetic architecture of haematological phenotype variation in swine and in humans.
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