化学
环加成
天然产物
生物合成
立体选择性
Diels-Alder反应
组合化学
有机化学
催化作用
酶
作者
Kévin Cottet,Maria Kolympadi,Dean Marković,Marie‐Christine Lallemand
标识
DOI:10.2174/1385272820666160331234709
摘要
The Diels-Alder cycloaddition is one of the most utilized reactions for the construction of cyclic systems with high regio-, chemo- and stereoselectivity. Accordingly, this versatile reaction has been broadly exploited in synthetic organic chemistry for the transformation of natural products, structurally diverse molecules of biological interests, pharmaceuticals, polymers and new materials. Nature has also used this cycloaddition reaction and Diels Alderase enzymes were proposed in many biosynthetic pathways of secondary metabolites. The aim of this account is to furnish to the scientific community an overview of reactions using a Diels Alderase for natural product biosynthesis. The proposed biosynthetic pathways involving Diels-Alder reaction are also summarized. Keywords: Natural products, biosynthesis, putative, Diels-Alder reaction.
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