活性氧
毛囊
再生(生物学)
血管生成
氧化应激
癌症研究
材料科学
肿瘤微环境
医学
药理学
化学
细胞生物学
生物
内科学
肿瘤细胞
作者
Anran Yuan,Fan Xia,Qiong Bian,Haibin Wu,Yueting Gu,Tao Wang,Ruxuan Wang,Lingling Huang,Qiaoling Huang,Yuefeng Rao,Daishun Ling,Fangyuan Li,Jianqing Gao
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-07-19
卷期号:15 (8): 13759-13769
被引量:109
标识
DOI:10.1021/acsnano.1c05272
摘要
Androgenetic alopecia (AGA) is highly prevalent in current society but lacks effective treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization in the perifollicular microenvironment is the leading cause of AGA. Herein, we designed a ceria nanozyme (CeNZ)-integrated microneedles patch (Ce-MNs) that can alleviate oxidative stress and promote angiogenesis simultaneously to reshape the perifollicular microenvironment for AGA treatment. On the basis of the excellent mechanical strength of Ce-MNs, the encapsulated CeNZs with catalase- and superoxide-mimic activities can be efficiently delivered into skin to scavenge excessive ROS. Moreover, the mechanical stimulation induced by the administration of MNs can remodel the microvasculature in the balding region. Compared with minoxidil, a widely used clinical drug for AGA treatment, Ce-MNs exhibited accelerated hair regeneration in the AGA mouse model at a lower administration frequency without inducing significant skin damage. Consequently, such a safe and perifollicular microenvironment-shaping MNs patch shows great potential for clinical AGA treatment.
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