Copper oxide nanoparticles synthesized from an endophytic fungus Aspergillus terreus: Bioactivity and anti-cancer evaluations

土曲霉 内生菌 DPPH 真菌 内生真菌在植物防御中的应用 MTT法 化学 抗氧化剂 生物 传统医学 体外 植物 微生物学 生物化学 医学
作者
Vellingiri Manon Mani,Sethumathavan Kalaivani,Sabarathinam Shanmugam,Manikandan Vasuki,Parimala Gnana Soundari Arockiam Jeyasundar,Mahuya Das,Ashraf Elfasakhany,Arivalagan Pugazhendhi
出处
期刊:Environmental Research [Elsevier BV]
卷期号:201: 111502-111502 被引量:52
标识
DOI:10.1016/j.envres.2021.111502
摘要

The mycofabricated metal nanoparticles (NPs) plays a significant role in cancer therapeutics and imparts a strategy in medicine. The current investigation focused to synthesize the Copper Oxide Nanoparticles (CuONPs) using an endophytic fungus isolated from Aegle marmelosa medicinal tree located in Western Ghats, India. The endophytic fungus FCBY1 explored the highest antagonistic and antioxidant activities among the 16 pigmented endophytic fungal strains which were isolated from the collected samples. The fungus FCBY1 was identified for its morphological and molecular characteristics where the (Internal Transcribed Spacer) ITS 1, 5.8 ribosomal gene and ITS 2 were sequenced; and the organism FCBY1 is Aspergillus terreus. The endophyte was put through for the synthesis of CuONPs and the size and structure of the synthesized particles were characterized by Scanning Electron Microscope (SEM). The confirmation of the CuONPs was characterized by FT-IR, EDAX and XRD analyses. The CuONPs exhibited the maximized antibacterial and antifungal activities against the human clinical pathogens; moreover the particles also explicated the free radicals/ROS scavenging at minimum concentration, which was assessed through DPPH, nitric oxide radical scavenging assays, and reductive power ability. The anti-cancer activity of CuONPs on colon cancer cell lines (HT-29) was evaluated by MTT (IC50: 22 μg/mL) and FACS analyses (32.11% cells gated in S phase of cell cycle). Angiogenesis inhibition in tumor cells was estimated through in vivo HET- CAM assessment and the highest concentration 60 μL tested inhibited the blood vessels at the percentage of 31.36% and 81.81%. The CuONPs explicated the anti-cancer activities in a concentration – dependent manner and the results of this investigation manifest the significant role of the CuONPs in cancer therapeutics.
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