A review on preparations, properties, and applications of cis-ortho-hydroxyl polysaccharides hydrogels crosslinked with borax

Polysaccharides-based hydrogel has many advantages such as biocompatibility, self-repair property, and biodegradability. It has been widely applied in various fields and has attracted great attention of researchers. The natural polysaccharides involved in this review include fenugreek gum, guar gum, locust bean gum, gellan gum, sodium alginate, agarose, and konjac glucomannan etc. Borax is a highly effective crosslinking agent for cis-ortho-hydroxyl polysaccharides. This paper focused on the synthesis mechanism, functional additives, characteristics, and applications of borax crosslinked cis-ortho-hydroxyl polysaccharides hydrogels (BHs). Moreover, the factors affecting BHs performance such as temperature, pH, and media were analyzed. Its mechanical and self-repair properties are enhanced by the dynamic and reversible borate/di-diol, which play a significant role in sensors, biomedicine, and tissue engineering. This review summarizes the research progress of BHs for the first time. Additionally, hoping to contribute to the development of this field, the review analyzes the correlation of performance through the SPSS 26 software.