In this study, the flow structure and effect of different pump rotational speeds on a centrifugal pump’s performance are experimentally and numerically investigated. The internal flow field pattern within the pump has been analyzed and discussed using the CFD technique. The numerical results are compared with experimental data under a wide range of operating conditions. The comparison results between them have indicated a considerable agreement. The pressure variations are gradually increasing from inlet to outlet impeller of the pump. The results note that when the impeller rotates near the tongue region, the pressure in this region was higher than in other parts. Also, the interaction between the impeller and volute tongue region is actually according to the impeller blades’ relative position concerning the tongue region. Furthermore, the pressure and velocity variations within a centrifugal pump increase with rotational impeller speed.