Correlation of post-stroke fatigue with glucose, homocysteine and functional disability

Background Our aim was to clarify the correlation between fatigue during the acute stage of stroke with serum glucose and homocysteine (Hcy) levels and functional disability. Materials and Methods A case group of 214 patients and a control group of 214 subjects were recruited during the same period. The serum glucose, Hcy, blood lipid and fibrinogen (FIB) levels of patients were determined. Fatigue was assessed using the Fatigue Severity Scale (FSS). Patients with an FSS score ≥4 points were defined as having fatigue. Stroke severity and the level of functional disability were assessed with the National Institutes of Health Stroke Scale (NIHSS) and the Barthel-20 Index (BI-20), respectively. Results The incidence of fatigue in the case group was higher than that in the control group (P < 0.001). Within the case group, the fatigue group showed higher serum levels of glucose and Hcy, and a lower BI-20 score compared to the non-fatigue group (P < 0.001). Age, gender, chronic disease history, the NIHSS score and the serum blood lipid and FIB levels were not significantly different between the two groups. In the fatigue group, the serum glucose and Hcy levels showed a positive effect and the BI-20 score showed a negative effect on the FSS score (P < 0.01). Age, gender, chronic disease history, the NIHSS score and the serum blood lipid and FIB levels did not significantly affect the FSS score. Conclusions The serum glucose and Hcy levels and functional disability are closely related to fatigue during the acute stage of ischaemic stroke.