亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

神经发生 海马结构 慢性应激 神经科学 心理学 抗抑郁药 5-羟色胺能 无血性 背景(考古学) 海马体 情绪障碍 抑郁症动物模型 血清素 内科学 医学 焦虑 内分泌学 精神科 生物 多巴胺 古生物学 受体
作者
Ian Mahar,Francis Rodriguez Bambico,Naguib Mechawar,José N. Nóbrega
出处
期刊:Neuroscience & Biobehavioral Reviews [Elsevier]
卷期号:38: 173-192 被引量:586
标识
DOI:10.1016/j.neubiorev.2013.11.009
摘要

Chronic stressful life events are risk factors for developing major depression, the pathophysiology of which is strongly linked to impairments in serotonin (5-HT) neurotransmission. Exposure to chronic unpredictable stress (CUS) has been found to induce depressive-like behaviours, including passive behavioural coping and anhedonia in animal models, along with many other affective, cognitive, and behavioural symptoms. The heterogeneity of these symptoms represents the plurality of corticolimbic structures involved in mood regulation that are adversely affected in the disorder. Chronic stress has also been shown to negatively regulate adult hippocampal neurogenesis, a phenomenon that is involved in antidepressant effects and regulates subsequent stress responses. Although there exists an enormous body of data on stress-induced alterations of 5-HT activity, there has not been extensive exploration of 5-HT adaptations occurring presynaptically or at the level of the raphe nuclei after exposure to CUS. Similarly, although hippocampal neurogenesis is known to be negatively regulated by stress and positively regulated by antidepressant treatment, the role of neurogenesis in mediating affective behaviour in the context of stress remains an active area of investigation. The goal of this review is to link the serotonergic and neurogenic hypotheses of depression and antidepressant effects in the context of stress. Specifically, chronic stress significantly attenuates 5-HT neurotransmission and 5-HT1A autoreceptor sensitivity, and this effect could represent an endophenotypic hallmark for mood disorders. In addition, by decreasing neurogenesis, CUS decreases hippocampal inhibition of the hypothalamic–pituitary–adrenal (HPA) axis, exacerbating stress axis overactivity. Similarly, we discuss the possibility that adult hippocampal neurogenesis mediates antidepressant effects via the ventral (in rodents; anterior in humans) hippocampus’ influence on the HPA axis, and mechanisms by which antidepressants may reverse chronic stress-induced 5-HT and neurogenic changes. Although data are as yet equivocal, antidepressant modulation of 5-HT neurotransmission may well serve as one of the factors that could drive neurogenesis-dependent antidepressant effects through these stress regulation-related mechanisms.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
just123发布了新的文献求助10
14秒前
27秒前
35秒前
GRATE完成签到 ,获得积分10
38秒前
45秒前
59秒前
1分钟前
丘比特应助科研通管家采纳,获得10
1分钟前
Si发布了新的文献求助10
1分钟前
ala完成签到,获得积分10
1分钟前
1分钟前
俏皮的飞烟完成签到,获得积分20
1分钟前
Si完成签到,获得积分10
2分钟前
2分钟前
2分钟前
3分钟前
SciGPT应助忧心的寄松采纳,获得10
3分钟前
标致诗双发布了新的文献求助10
3分钟前
3分钟前
3分钟前
ljjyy发布了新的文献求助10
3分钟前
lovelife完成签到,获得积分10
3分钟前
3分钟前
3分钟前
zai完成签到 ,获得积分10
3分钟前
3分钟前
kyfbrahha完成签到 ,获得积分10
3分钟前
4分钟前
4分钟前
4分钟前
胡娇发布了新的文献求助10
4分钟前
taoxz521完成签到 ,获得积分10
4分钟前
标致诗双完成签到,获得积分10
4分钟前
Noctis发布了新的文献求助10
4分钟前
5分钟前
情怀应助科研通管家采纳,获得10
5分钟前
5分钟前
踏实的研完成签到,获得积分10
5分钟前
研友_闾丘枫完成签到 ,获得积分10
5分钟前
5分钟前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Free Will in the Flesh 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081568
求助须知:如何正确求助?哪些是违规求助? 2734399
关于积分的说明 7532720
捐赠科研通 2383882
什么是DOI,文献DOI怎么找? 1264075
科研通“疑难数据库(出版商)”最低求助积分说明 612561
版权声明 597578