氧化应激
内质网
未折叠蛋白反应
自噬
PI3K/AKT/mTOR通路
肌肉肥大
药理学
压力过载
化学
体内
医学
细胞生物学
细胞凋亡
心肌肥大
内科学
生物
生物化学
生物技术
作者
Dongjian Han,Fuhang Wang,Bo Wang,Zhentao Qiao,Xinyue Cui,Yi Zhang,Qingjiao Jiang,Miaomiao Liu,Jiahong Shangguan,Xiaohui Zheng,Yajun Bai,Caigan Du,Deliang Shen
标识
DOI:10.3389/fphar.2022.830763
摘要
Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects. However, its effects on cardiac hypertrophy are not well understood. In this work, we investigated the treatment effects and potential mechanisms of DBZ on the hypertrophic heart under oxidative stress and endoplasmic reticulum (ER) stress. A hypertrophic model was established in rats using transverse-aortic constriction (TAC) surgery and in neonatal rat cardiomyocytes (NRCMs) using angiotensin II (Ang II). Our results revealed that DBZ remarkably inhibited oxidative stress and ER stress, blocked autophagy flow, and decreased apoptosis in vivo and in vitro through nuclear NRF2 accumulation, and enhanced NRF2 stability via regulating the mTOR/β-TrcP/NRF2 signal pathway. Thus, DBZ may serve as a promising therapeutic for stress-induced cardiac hypertrophy.
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