光热治疗
吲哚青绿
热疗
乳腺癌
医学
脂质体
药物输送
癌症
光热效应
药理学
癌症研究
内科学
病理
材料科学
纳米技术
作者
Yan Huang,Qianying Zhang,Pingyun Feng,Weihuan Li,Xiuru Li,Yongjie Li,Di Zhang
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2023-02-01
卷期号:20 (2): 192-200
标识
DOI:10.2174/1567201819666220411115632
摘要
High mortality and limited therapeutic efficacy of clinical treatment make breast cancer a stubborn disease in women. The hypovascular issue is the main challenge needed to be overcome in breast cancer treatment.For this purpose, hyperthermia-sensitive liposomes containing indocyanine green (ICG) and brucea javanica oil (BJO) (LP(BJO/ICG)) were constructed for near-infrared (NIR) laser-induced photothermal- /chemo-antitumor therapy. ICG, an FDA-approved photothermal agent, was employed in this study to perform photothermal therapy (PTT) effect as well as relieve hypovascular conditions in breast cancer tissue.BJO triggered release from the hyperthermia-sensitive LP (BJO/ICG) due to disassembly of liposomes under the PTT effect caused by ICG under NIR laser irradiation. It was found that mice in LP (BJO/ICG) group showed the slowest tumor growth under NIR laser irradiation, illustrating the strongest antitumor effect among all groups.This responsive-release drug delivery platform can be a promising candidate for the treatment of breast cancer.
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