热带疾病
血吸虫病
生物
血吸虫
生物标志物
被忽视的热带疾病
寄生虫病
曼氏血吸虫
免疫学
唾液
疾病
蠕虫病
分子诊断学
病毒学
生物信息学
蠕虫
病理
医学
遗传学
生物化学
作者
Hanif Ullah,Safia Arbab,Ka Wan Li,Muhammad Shahzeb Khan,Abdul Qadeer,Nehaz Muhammad
标识
DOI:10.1016/j.molbiopara.2022.111495
摘要
Schistosoma is a genus of trematodes causing schistosomiasis, a major neglected tropical disease infecting more than 240 million people and with 700 million people at the risk of infection in the tropical and subtropical regions of the world, especially low-income countries. For the elimination of the disease, accurate diagnostic tools are needed. Besides allowing early treatment, early detection prevents environmental contamination and in turn ensures safe water sources in the endemic areas. Cell-free DNA (cfDNA) biomarker detection is a relatively new tool, used for the diagnosis of schistosomiasis in the early stages of infection from non-invasive clinical or experimental samples. cfDNA can be detected in Schistosoma infected host body fluids such as urine, serum, saliva and tissues, mainly in blood offering significant benefits for accurate diagnosis. In the current review, we described different characteristics of cfDNA, evidencing and supporting its potential uses in Schistosoma diagnosis and the improvement of treatment effectiveness.
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