Competitive and cooperative games for probing the neural basis of social decision-making in animals

In a social environment, it is essential for animals to consider the behavior of others when making decisions. To quantitatively assess such social decisions, games offer unique advantages. Games may have competitive and cooperative components, modeling situations with antagonistic and shared objectives between players. Games can be analyzed by mathematical frameworks, including game theory and reinforcement learning, such that an animal's choice behavior can be compared against the optimal strategy. However, so far games have been underappreciated in neuroscience research, particularly for rodent studies. In this review, we survey the varieties of competitive and cooperative games that have been tested, contrasting strategies employed by non-human primates and birds with rodents. We provide examples of how games can be used to uncover neural mechanisms and explore species-specific behavioral differences. We assess critically the limitations of current paradigms and propose improvements. Together, the synthesis of current literature highlights the advantages of using games to probe the neural basis of social decisions for neuroscience studies.