伤口愈合
炎症
巨噬细胞
免疫系统
皮肤修复
医学
纤维化
免疫学
表型
生物
病理
体外
基因
生物化学
作者
Alireza Hassanshahi,Mohammad Moradzad,Saman Ghalamkari,Moosa Fadaei,Allison J. Cowin,Mohammadhossein Hassanshahi
出处
期刊:Cells
[MDPI AG]
日期:2022-09-21
卷期号:11 (19): 2953-2953
被引量:93
标识
DOI:10.3390/cells11192953
摘要
Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound healing through the transitioning from predominantly pro-inflammatory (M1-like phenotypes), which present early post-injury, to anti-inflammatory (M2-like phenotypes), which appear later to modulate skin repair and wound closure. In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. We also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing. Understanding and harnessing the activity and capability of macrophages may help to advance new approaches for improving healing of the skin.
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