自愈水凝胶
生物相容性
伤口愈合
细胞外小泡
胞外囊泡
纳米技术
材料科学
控制释放
生物医学工程
医学
化学
外科
细胞生物学
生物
生物化学
小RNA
微泡
基因
高分子化学
冶金
作者
Zhenzhen Yan,Tinglin Zhang,Yuxiang Wang,Shichu Xiao,Jie Gao
标识
DOI:10.1016/j.mtbio.2023.100810
摘要
Diabetic wounds (DWs) pose a major challenge for the public health system owing to their high incidence, complex pathogenesis, and long recovery time; thus, there is an urgent need to develop innovative therapies to accelerate the healing process of diabetic wounds. As natural nanovesicles, extracellular vesicles (EVs) are rich in sources with low immunogenicity and abundant nutritive molecules and exert potent therapeutic effects on diabetic wound healing. To avoid the rapid removal of EVs, a suitable delivery system is required for their controlled release. Owing to the advantages of high porosity, good biocompatibility, and adjustable physical and chemical properties of hydrogels, EV biopotentiated hydrogels can aid in achieving precise and favorable therapy against diabetic wounds. This review highlights the different design strategies, therapeutic effects, and mechanisms of EV biopotentiated hydrogels. We also discussed the future challenges and opportunities of using EV biopotentiated hydrogels for diabetic wound healing.
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