三氟甲磺酸
碳阳离子
化学
硅烷
质子化
选择性
氢化物
组合化学
催化作用
有机化学
光化学
金属
离子
作者
Jianxin Hou,Xue Han⊗,Yiyi Zhang,Jiahui Huang,Jiawei Wang,Kedong Yuan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-08-01
卷期号:25 (31): 5709-5713
被引量:7
标识
DOI:10.1021/acs.orglett.3c01762
摘要
Deoxygenative transformation of ketones into value-added products often suffers from precious-metal-based catalysts or complicated operational conditions. Triflic acid and silane serve as a cooperative reductant to transform ketones via carbocations that undergo β-H elimination much faster than hydride transfer from silane to produce alkenes with high selectivity. Alternatively, the presence of indoles would incept the protonated ketones to generate carbocations, allowing access to Csp2–Csp3 bond formation with high reactivity and selectivity in "one pot".
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