Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy

医学 内科学 心脏病学 血管内超声 心肌梗塞 阿利罗库单抗 动脉粥样硬化 相伴的 安慰剂 胆固醇 脂蛋白 病理 替代医学 载脂蛋白A1
作者
Flavio Giuseppe Biccirè,Jonas Häner,Sylvain Losdat,Yasushi Ueki,Hiroki Shibutani,Tatsuhiko Otsuka,Ryota Kakizaki,Thomas M. Hofbauer,Robert‐Jan van Geuns,Stefan Stortecky,George C.M. Siontis,Sarah Bär,Jacob Lønborg,Dik Heg,Christoph Kaiser,David Spirk,Joost Daemen,Juan F. Iglesias,Stephan Windecker,Thomas Engstrøm
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:82 (18): 1737-1747 被引量:49
标识
DOI:10.1016/j.jacc.2023.08.019
摘要

The frequency, characteristics, and outcomes of patients treated with high-intensity lipid-lowering therapy and showing concomitant atheroma volume reduction, lipid content reduction, and increase in fibrous cap thickness (ie, triple regression) are unknown.This study was designed to investigate rates, determinants, and prognostic implications of triple regression in patients presenting with acute myocardial infarction and treated with high-intensity lipid-lowering therapy.The PACMAN-AMI (Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction) trial used serial intravascular ultrasound, near-infrared spectroscopy, and optical coherence tomography to compare the effects of alirocumab vs placebo in patients receiving high-intensity statin therapy. Triple regression was defined by the combined presence of percentage of atheroma volume reduction, maximum lipid core burden index within 4 mm reduction, and minimal fibrous cap thickness increase. Clinical outcomes at 1-year follow-up were assessed.Overall, 84 patients (31.7%) showed triple regression (40.8% in the alirocumab group vs 23.0% in the placebo group; P = 0.002). On-treatment low-density lipoprotein cholesterol levels were lower in patients with vs without triple regression (between-group difference: -27.1 mg/dL; 95% CI: -37.7 to -16.6 mg/dL; P < 0.001). Triple regression was independently predicted by alirocumab treatment (OR: 2.83; 95% CI: 1.57-5.16; P = 0.001) and a higher baseline maximum lipid core burden index within 4 mm (OR: 1.03; 95% CI: 1.01-1.06; P = 0.013). The composite clinical endpoint of death, myocardial infarction, and ischemia-driven revascularization occurred less frequently in patients with vs without triple regression (8.3% vs 18.2%; P = 0.04).Triple regression occurred in one-third of patients with acute myocardial infarction who were receiving high-intensity lipid-lowering therapy and was associated with alirocumab treatment, higher baseline lipid content, and reduced cardiovascular events. (Vascular Effects of Alirocumab in Acute MI-Patients [PACMAN-AMI]; NCT03067844).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zhouzi180发布了新的文献求助20
刚刚
武雨寒完成签到,获得积分20
1秒前
狂风阿来完成签到 ,获得积分10
1秒前
小马甲应助双景采纳,获得10
2秒前
3秒前
飘逸善若完成签到,获得积分10
4秒前
5秒前
Akim应助尊敬的凌晴采纳,获得10
6秒前
大个应助西子阳采纳,获得10
6秒前
武雨寒发布了新的文献求助10
6秒前
6秒前
6秒前
uon完成签到,获得积分10
7秒前
8秒前
Jasper应助ws5995采纳,获得10
8秒前
10秒前
10秒前
10秒前
10秒前
Orange应助RXwang采纳,获得10
11秒前
姚开元完成签到,获得积分10
11秒前
11秒前
AAAAA发布了新的文献求助10
12秒前
Liufgui应助QQ采纳,获得20
13秒前
JamesPei应助why采纳,获得10
13秒前
愉快竺完成签到 ,获得积分10
15秒前
15秒前
xueyu完成签到,获得积分10
15秒前
领导范儿应助小狗采纳,获得10
17秒前
lj发布了新的文献求助10
18秒前
Pursue。发布了新的文献求助10
18秒前
fst发布了新的文献求助10
19秒前
俊俊完成签到,获得积分10
22秒前
英俊的铭应助wp4455777采纳,获得10
22秒前
22秒前
yoke完成签到,获得积分10
22秒前
24秒前
24秒前
和谐续完成签到 ,获得积分10
24秒前
雷霆嘎巴完成签到,获得积分10
25秒前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
Problems of point-blast theory 400
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
The Cambridge Handbook of Social Theory 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3999530
求助须知:如何正确求助?哪些是违规求助? 3538968
关于积分的说明 11275514
捐赠科研通 3277819
什么是DOI,文献DOI怎么找? 1807686
邀请新用户注册赠送积分活动 884100
科研通“疑难数据库(出版商)”最低求助积分说明 810138