红藻氨酸受体
AMPA受体
致电离效应
肌萎缩侧索硬化
神经科学
谷氨酸受体
长期抑郁
癫痫
受体
医学
生物
疾病
内科学
作者
Marina N. Vukolova,Laura Y. Yen,Margarita I. Khmyz,Alexander I. Sobolevsky,M.V. Yelshanskaya
标识
DOI:10.3389/fcell.2023.1252953
摘要
Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors, in the pathogenesis and treatment of Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis. Although both AMPA and kainate receptors represent promising therapeutic targets for the treatment of these diseases, many of their antagonists show adverse side effects. Further studies of factors affecting the selective subunit expression and trafficking of AMPA and kainate receptors, and a reasonable approach to their regulation by the recently identified novel compounds remain promising directions for pharmacological research.
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