Updated Meta-Analysis Assessing the Cardiovascular Efficacy of Tirzepatide

Type 2 diabetes mellitus (T2DM) is a chronic, progressive, metabolic disorder, associated with the development of both microvascular and macrovascular complications. T2DM is closely related to cardiovascular disease, which is the leading cause of death among affected patients. 1 Joseph JJ Deedwania P Acharya T Aguilar D Bhatt DL Chyun DA Di Palo KE Golden SH Sperling LS American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Clinical Cardiology; and Council on HypertensionComprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement From the American Heart Association. Circulation. 2022; 145: e722-e759 Crossref PubMed Scopus (142) Google Scholar Overweight or obesity is a common co-morbid condition in patients with T2DM, which leads to greater increase in cardiovascular and all-cause mortality, compared with patients with T2DM who follow a healthier lifestyle. 2 Zhang Y Pan XF Chen J Xia L Cao A Zhang Y Wang J Li H Yang K Guo K He M Pan A. Combined lifestyle factors and risk of incident type 2 diabetes and prognosis among individuals with type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Diabetologia. 2020; 63: 21-33 Crossref PubMed Scopus (142) Google Scholar However, obesity is an independent risk factor for cardiovascular disease, without requiring the presence of background T2DM. 3 Ortega FB Lavie CJ Blair SN. Obesity and cardiovascular disease. Circ Res. 2016; 118: 1752-1770 Crossref PubMed Scopus (709) Google Scholar