氮氧化物4
糖尿病
微血管病
糖尿病性视网膜病变
医学
糖尿病肾病
糖尿病血管病
糖尿病性心肌病
NADPH氧化酶
肾病
大血管病
生物信息学
氧化应激
疾病
内科学
内分泌学
2型糖尿病
心肌病
生物
心力衰竭
作者
Dongxia Wang,Jiaying Li,Gang Luo,Juan Zhou,Ning Wang,Shanshan Wang,Rui Zhao,Xin Cao,Yuxia Ma,Gang Liu,Liping Hao
出处
期刊:Redox biology
[Elsevier]
日期:2023-06-09
卷期号:64: 102781-102781
被引量:19
标识
DOI:10.1016/j.redox.2023.102781
摘要
Diabetic vascular complications can affect both microvascular and macrovascular. Diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and diabetic cardiomyopathy, are believed to be caused by oxidative stress. The Nox family of NADPH oxidases is a significant source of reactive oxygen species and plays a crucial role in regulating redox signaling, particularly in response to high glucose and diabetes mellitus. This review aims to provide an overview of the current knowledge about the role of Nox4 and its regulatory mechanisms in diabetic microangiopathies. Especially, the latest novel advances in the upregulation of Nox4 that aggravate various cell types within diabetic kidney disease will be highlighted. Interestingly, this review also presents the mechanisms by which Nox4 regulates diabetic microangiopathy from novel perspectives such as epigenetics. Besides, we emphasize Nox4 as a therapeutic target for treating microvascular complications of diabetes and summarize drugs, inhibitors, and dietary components targeting Nox4 as important therapeutic measures in preventing and treating diabetic microangiopathy. Additionally, this review also sums up the evidence related to Nox4 and diabetic macroangiopathy.
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