抗菌剂
黄酮类
金黄色葡萄球菌
异黄酮素
黄酮醇
耐甲氧西林金黄色葡萄球菌
微生物学
传统医学
类黄酮
生物
医学
细菌
生物化学
植物
抗氧化剂
遗传学
作者
Shengnan Xu,Andrew H. Kang,Yue Tian,Xia Li,Shangshang Qin,Ruige Yang,Yong Guo
出处
期刊:ACS Infectious Diseases
[American Chemical Society]
日期:2024-06-04
被引量:2
标识
DOI:10.1021/acsinfecdis.4c00292
摘要
Methicillin-resistant Staphylococcus aureus (MRSA) has become a serious threat to human public health and global economic development, and there is an urgent need to develop new antimicrobial agents. Flavonoids are the largest group of plant secondary metabolites, and the anti-S. aureus and anti-MRSA activities of flavonoids have now been widely reported. The aim of this Review is to describe plant-derived flavonoid active ingredients and their effects and mechanisms of inhibitory activity against MRSA in order to provide insights for screening novel antimicrobial agents. Here, 85 plant-derived flavonoids (14 flavones, 21 flavonols, 26 flavanones, 9 isoflavones, 12 chalcones, and 3 other classes) with anti-MRSA activity are reviewed. Among these flavonoids, flavones and isoflavones generally showed the most significant anti-MRSA activity (MICs: 1–8 μg/mL). The results of the present Review display that most of the flavonoids with excellent anti-MRSA activity were derived from Morus alba L. and Paulownia tomentosa (Thunb.) Steud. The antibacterial mechanism of flavonoids against MRSA is mainly achieved by disruption of membrane structures, inhibition of efflux pumps, and inhibition of β-lactamases and bacterial virulence factors. We hope this Review can provide insights into the development of novel antimicrobials based on natural products for treating MRSA infections.
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