生物
基因
先天免疫系统
基因表达谱
基因家族
遗传学
基因组
系统发育树
基因表达
计算生物学
受体
作者
Zhentao Chen,Xuangang Wang,Gan Yu,Jingrun Pu,Xuechen Li,Ze Tao,Zhixiang Duan,Fan Zhang,Ping Han,Hengshun Li,Haiyang Yu
标识
DOI:10.1016/j.fsi.2024.109686
摘要
The scavenger receptors (SRs) gene family is considered as the membrane-associated pattern recognition receptors that plays important roles in the immune responses of organisms. However, there is currently limited research on the systematic identification of the SRs gene family in teleost and their role in the innate immunity of S. schegelii. In this study, we identified and annotated 15 SRs genes in S. schegelii. Through phylogenetic analysis, analysis of conserved domains, gene structure, and motif composition, we found that SRs gene family within different classes were relatively conserved. Additionally, we used qRT-PCR to analyze the expression patterns of SRs genes in immune-related tissues from healthy and Acinetobacter johnsonii-infected S. schegelii. The results showed that SRs genes exhibited different tissue expression patterns and the expression of SRs genes significantly changed after A. johnsonii infection. These results provided a valuable basis for further understanding of the functions of SRs in the innate immune response of S. schegelii.
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