Association of Supranormal Left Ventricular Function With Major Adverse Cardiovascular Events: A Systematic Review of Literature

This systematic review aims to assess the prognostic implications of supranormal left ventricular ejection fraction (snLVEF) in cardiovascular disease, particularly heart failure (HF), and explore its association with major adverse cardiovascular events (MACE). A comprehensive search of electronic databases was conducted to identify relevant studies examining the relationship between snLVEF and cardiovascular outcomes. Studies utilizing various imaging modalities, including echocardiography, cardiac positron emission tomography, computed tomography, and cardiac magnetic resonance imaging, were included. Data extraction and quality assessment were performed according to predefined criteria. The review identified several studies investigating the association between snLVEF and cardiovascular outcomes. Findings revealed an increased risk of MACE, including HF hospitalization and stroke, in patients with snLVEF, particularly in women. Coronary microvascular dysfunction and autonomic dysregulation were proposed mechanisms underlying these associations. However, conflicting results were observed when focusing exclusively on snLVEF, with some studies reporting similar outcomes between snLVEF and other HF subgroups. snLVEF (>65%) appears to be associated with an elevated risk of MACE, particularly in women, suggesting a U-shaped mortality curve. However, the prognostic implications may vary among HF patients, necessitating further research to elucidate the specific contributions of HF phenotypes and comorbidities. These findings underscore the importance of tailored risk assessment and management strategies for patients with snLVEF, particularly in the context of HF.