亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

FDG PET/CT parameters and CA-125 levels to predict optimal cytoreduction at primary cytoreductive surgery for advanced ovarian cancer (149)

医学 阶段(地层学) 卵巢癌 接收机工作特性 浆液性液体 曲线下面积 放射科 肾静脉 核医学 癌症 泌尿科 内科学 古生物学 生物
作者
Junhwan Kim,Maria Lee,Se Ik Kim,Joonhyung Gil,Jae‐Weon Kim,Gi Jeong Cheon
出处
期刊:Gynecologic Oncology [Elsevier BV]
卷期号:166: S91-S91
标识
DOI:10.1016/s0090-8258(22)01376-2
摘要

Objectives: To develop models predicting optimal cytoreduction in primary cytoreductive surgery (CRS) using clinical-pathologic characteristics and FDG PET/CT-derived parameters in advanced ovarian cancer. Methods: We retrospectively identified patients with stage III-IV ovarian cancer who underwent primary CRS between June 2013 and February 2020 at our center. We calculated the following 18 parameters: maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), visual grade, and the number of lesions in three divided areas of the abdominal cavity. Optimal cytoreduction was defined as grossly no residual tumor after CRS. We constructed various predictive models for optimal cytoreduction by combining clinical-pathologic characteristics and FDG PET/CT-derived parameters. The predictive performance of each model was assessed based on the area under the receiver operating characteristic curve (AUC). Results: In total, 159 patients were included in the study. The median age was 55 years. The most common histologic subtype was serous (74.2%). Stage III and stage IV were 73.6% and 26.4%, respectively. Optimal cytoreduction was achieved in 104 patients (65.4%). The median CA-125 was 764 IU/ml. As a single variable, MTV, TLG, number of lesions above the renal vein showed high AUC for optimal cytoreduction, at 0.749, 0.748, and 0.748, respectively. The best predictive multivariable model consisted of CA-125 (<750 or ≥750 IU/ml), the number of lesions above the renal vein (<2 or ≥2), and MTV above the renal vein with an AUC of 0.770 for optimal cytoreduction. Conclusions: We successfully developed FDG PET/CT-based predictive model for optimal cytoreduction. This result may help determine patients’ treatment plans. Objectives: To develop models predicting optimal cytoreduction in primary cytoreductive surgery (CRS) using clinical-pathologic characteristics and FDG PET/CT-derived parameters in advanced ovarian cancer. Methods: We retrospectively identified patients with stage III-IV ovarian cancer who underwent primary CRS between June 2013 and February 2020 at our center. We calculated the following 18 parameters: maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), visual grade, and the number of lesions in three divided areas of the abdominal cavity. Optimal cytoreduction was defined as grossly no residual tumor after CRS. We constructed various predictive models for optimal cytoreduction by combining clinical-pathologic characteristics and FDG PET/CT-derived parameters. The predictive performance of each model was assessed based on the area under the receiver operating characteristic curve (AUC). Results: In total, 159 patients were included in the study. The median age was 55 years. The most common histologic subtype was serous (74.2%). Stage III and stage IV were 73.6% and 26.4%, respectively. Optimal cytoreduction was achieved in 104 patients (65.4%). The median CA-125 was 764 IU/ml. As a single variable, MTV, TLG, number of lesions above the renal vein showed high AUC for optimal cytoreduction, at 0.749, 0.748, and 0.748, respectively. The best predictive multivariable model consisted of CA-125 (<750 or ≥750 IU/ml), the number of lesions above the renal vein (<2 or ≥2), and MTV above the renal vein with an AUC of 0.770 for optimal cytoreduction. Conclusions: We successfully developed FDG PET/CT-based predictive model for optimal cytoreduction. This result may help determine patients’ treatment plans.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
11发布了新的文献求助10
4秒前
CipherSage应助miles采纳,获得10
7秒前
周游完成签到 ,获得积分10
10秒前
10秒前
15秒前
huihongzeng发布了新的文献求助10
18秒前
Judy完成签到 ,获得积分10
21秒前
利物鸟贝拉完成签到,获得积分10
22秒前
24秒前
Esperanza完成签到,获得积分10
25秒前
miles发布了新的文献求助10
27秒前
30秒前
鹿茸与共发布了新的文献求助10
36秒前
43秒前
jianghs完成签到,获得积分10
53秒前
科目三应助11采纳,获得10
54秒前
jianghs发布了新的文献求助10
57秒前
1分钟前
feifei完成签到,获得积分10
1分钟前
feifei发布了新的文献求助10
1分钟前
福娃哇完成签到 ,获得积分10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
科目三应助科研通管家采纳,获得10
1分钟前
1分钟前
草莓熊1215完成签到 ,获得积分10
1分钟前
青竹完成签到,获得积分10
1分钟前
旺仔先生完成签到 ,获得积分10
1分钟前
1分钟前
candy teen完成签到,获得积分10
1分钟前
垃圾桶完成签到 ,获得积分10
1分钟前
李健应助含蓄绿竹采纳,获得10
1分钟前
和谐的小松鼠完成签到,获得积分10
1分钟前
Oculus完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
含蓄绿竹发布了新的文献求助10
2分钟前
有机发布了新的文献求助10
2分钟前
俊逸沛菡完成签到 ,获得积分10
2分钟前
2分钟前
可靠雨文发布了新的文献求助10
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990015
求助须知:如何正确求助?哪些是违规求助? 3532077
关于积分的说明 11256227
捐赠科研通 3270933
什么是DOI,文献DOI怎么找? 1805139
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228