热休克蛋白90
癌变
热休克蛋白
Hsp90抑制剂
癌症研究
恶性肿瘤
格尔德霉素
癌症
生物
癌症治疗
癌细胞
生物信息学
医学
生物化学
遗传学
基因
作者
Xiude Ren,Tao Li,Wei Zhang,Xuejun Yang
出处
期刊:Cells
[MDPI AG]
日期:2022-08-17
卷期号:11 (16): 2556-2556
被引量:18
标识
DOI:10.3390/cells11162556
摘要
Heat-shock protein 90 (HSP90) is an important molecule chaperone associated with tumorigenesis and malignancy. HSP90 is involved in the folding and maturation of a wide range of oncogenic clients, including diverse kinases, transcription factors and oncogenic fusion proteins. Therefore, it could be argued that HSP90 facilitates the malignant behaviors of cancer cells, such as uncontrolled proliferation, chemo/radiotherapy resistance and immune evasion. The extensive associations between HSP90 and tumorigenesis indicate substantial therapeutic potential, and many HSP90 inhibitors have been developed. However, due to HSP90 inhibitor toxicity and limited efficiency, none have been approved for clinical use as single agents. Recent results suggest that combining HSP90 inhibitors with other anticancer therapies might be a more advisable strategy. This review illustrates the role of HSP90 in cancer biology and discusses the therapeutic value of Hsp90 inhibitors as complements to current anticancer therapies.
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