黄原酮
芒果藤黄
化学
赫拉
乙酸乙酯
藤黄属
葡聚糖
硅胶
柱色谱法
细胞毒性
色谱法
立体化学
高效液相色谱法
乙醇
夜蛾科
有机化学
传统医学
生物化学
植物
体外
生物
医学
酶
作者
Feng-Ning Zhao,Qi Niu,Die Xiao,Haonan Xu,Haoxin Wang,Rong-Lu Bi,Hongping He,Zhiyong Jiang
出处
期刊:PubMed
日期:2023-11-01
卷期号:48 (21): 5817-5821
标识
DOI:10.19540/j.cnki.cjcmm.20230805.201
摘要
Eight compounds were isolated from ethyl acetate fraction of 80% ethanol extract of the hulls of Garcinia mangostana by silica gel, Sephadex LH-20 column chromatography, as well as prep-HPLC methods. By HR-ESI-MS, MS, 1D and 2D NMR spectral analyses, the structures of the eight compounds were identified as 16-en mangostenone E(1), α-mangostin(2), 1,7-dihydroxy-2-(3-methy-lbut-2-enyl)-3-methoxyxanthone(3), cratoxyxanthone(4), 2,6-dimethoxy-para-benzoquinone(5), methyl orselinate(6), ficusol(7), and 4-(4-carboxy-2-methoxyphenoxy)-3,5-dimethoxybenzoic acid(8). Compound 1 was a new xanthone, and compound 4 was a xanthone dimer, compound 5 was a naphthoquinone. All compounds were isolated from this plant for the first time except compounds 2 and 3. Cytotoxic bioassay suggested that compounds 1, 2 and 4 possessed moderate cytotoxicity, suppressing HeLa cell line with IC_(50) va-lues of 24.3, 35.5 and 17.1 μmol·L~(-1), respectively. Compound 4 also could suppress K562 cells with an IC_(50) value of 39.8 μmol·L~(-1).
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