光动力疗法
光化学
荧光
催化作用
猝灭(荧光)
光催化
电子转移
氧气
激发态
光敏剂
化学
材料科学
组合化学
有机化学
光学
物理
核物理学
作者
Jian Zhang,Jushuai Ma,Shuyue Zhang,Xiaoyan Lou,Yunshu Ding,Yong Li,Miaomiao Xu,Xilei Xie,Xiaoyun Jiao,Xueyu Dou,Xu Wang,Bo Tang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-11-27
卷期号:17 (23): 23430-23441
被引量:6
标识
DOI:10.1021/acsnano.3c05106
摘要
The mechanisms of action (MoA) have been proposed to further reduce the O2 dependence of photodynamic therapy (PDT) significantly. However, the triplet states of traditional photosensitizers are relatively short and also are easily deactivated by the quenching of H2O or O2. This is not conducive for the electron transfer in the photocatalytic process and poses a great obstacle to establish the MoA. Therefore, we selected and synthesized a zirconium(IV) complex (Zr(MesPDPPh)2) reported by Milsmann to address this issue. The specific symmetric and intact geometry endowed Zr(MesPDPPh)2 NPs with long-lived triplet excited state (τ = 350 μs), desired sensitized ability, and improved anti-interfering performance on O2, which was matched with the requirements of photoredox catalyst significantly. The results showed that while PDT (I) and PDT (II) could be achieved simultaneously by leveraging Zr(MesPDPPh)2 NPs, it also could be served as a rare example of thermally activated delayed fluorescence (TADF)-based photoredox catalyst to implement the MoA of PDT. It involved the oxidation of NADH and the establishment of catalytic cycle collaborating by O2 and cytochrome c (cyt c) in normoxia and hypoxia, respectively. As a result, the oxygen-free PDT and tumor-growth inhibition was realized.
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