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The Effect of 3-Dimensional–Printed Sequential Dual Drug–Releasing Patch on the Capsule Formation Around the Silicone Implant in a Rat Model

医学 包膜挛缩 植入 硅酮 胶囊 乳房植入物 抗生素 药物输送 药品 外科 药理学 微生物学 内科学 乳房再造术 材料科学 生物 植物 复合材料 癌症 乳腺癌 纳米技术
作者
Hyung Bae Kim,Yeonggwon Jo,Soo Hyun Woo,Se young Han,Sun Hyeok Lee,Young‐Tae Chang,Ju Young Park,Jinah Jang,Hyun Ho Han
出处
期刊:Aesthetic Surgery Journal [Oxford University Press]
标识
DOI:10.1093/asj/sjae008
摘要

Abstract Background Implant-based breast reconstruction is associated with increased risk of early infection and late-stage capsular contracture. Objectives We evaluated the feasibility of a dual drug–releasing patch that enabled the controlled delivery of antibiotics and immunosuppressants in a temporally and spatially appropriate manner to the implant site. Methods The efficacy of a dual drug–releasing patch, which was 3-dimensional–printed (3D-printed) with tissue-derived biomaterial ink, was evaluated in rats with silicone implants. The groups included implant only (n = 10); implant plus bacterial inoculation (n = 14); implant, bacterial inoculation, and patch loaded with gentamycin placed on the ventral side of the implant (n = 10), and implant, bacterial inoculation, and patch loaded with gentamycin and triamcinolone acetonide (n = 9). Histologic and immunohistochemical analyses were performed 8 weeks after implantation. Results The 2 drugs were sequentially released from the dual drug–releasing patch and exhibited different release profiles. Compared to the animals with bacterial inoculation, those with the antibiotic-only and the dual drug–releasing patch exhibited thinner capsules and lower myofibroblast activity and inflammation, indicating better tissue integration and less foreign body response. These effects were more pronounced with the dual drug–releasing patch than with the antibiotic-only patch. Conclusions The 3D-printed dual drug–releasing patch effectively reduced inflammation and capsule formation in a rat model of silicone breast reconstruction. The beneficial effect of the dual drug–releasing patch was better than that of the antibiotic-only patch, indicating its therapeutic potential as a novel approach to preventing capsular contracture while reducing concerns of systemic side effects.
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