“One‐Pot” Synthesized Phosphorus Corrole‐Based Metal–Organic Frameworks for Synergistic Phototherapy and Chemodynamic Therapy

咔咯 光热治疗 化学 配体(生物化学) 光动力疗法 金属有机骨架 组合化学 卟啉 金属 光化学 纳米技术 材料科学 有机化学 受体 生物化学 吸附
作者
Wenbo Deng,Zixiang Wei,Yunhao Xu,Zhichao Gong,Fenglin Cai,Quan Shi,Kai Guo,Jia Meng,Yanming Zhao,Yaqing Feng,Jingyu Deng,Bao Zhang
出处
期刊:Small [Wiley]
标识
DOI:10.1002/smll.202408975
摘要

Abstract As a distinctive class of porphyrin derivatives, corroles offer exceptional potential in phototherapy applications owing to their unique electronic structures. However, developing metal–organic frameworks (MOFs) that incorporate photosensitive corroles as functional ligands for synergistic phototherapy remains a formidable challenge. Herein, for the first time, the unique phosphorus corrole‐based MOFs Cor(P)‐Hf with (3,18)‐connected gea topology are reported, which are constructed by Cs ‐symmetric dicarboxylate 3‐connected linkers, 10‐pentafluorophenyl‐5,15‐di( p ‐benzoate)phosphorus corrole (Cor(P)), and the peculiar D 3h ‐symmetric 18‐connected Hf 12 ‐oxo clusters. Interestingly, six para ‐position F substituents of six Cor(P) linkers are found to be coordinated with the apex of the Hf 12 ‐oxo cluster through Hf‐F bonds along the c‐axis direction, which is believed to help stabilize the framework. Furthermore, the mixed corrolic ligand‐based MOFs Cor(P)/Cor(Cu)‐Hf and Cor(P)/Cor(Fe)‐Hf involving Cor(Fe) or Cor(Cu) as the secondary functional linkers are constructed by a simple “one‐pot” solvent‐thermal method, respectively. Remarkably, Cor(P)/Cor(Fe)‐Hf facilitates synergistic phototherapy combining photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) when activated by an 808 nm laser, as evidenced by in vivo and in vitro experiments. This study demonstrates corrole‐based MOFs Cor(P)‐Hf as a powerful multifunctional nanoplatform for anti‐cancer phototherapy.
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