Structure-informed separation of bioactive peptides

保健品 生化工程 色谱分离 鉴定(生物学) 计算机科学 分离法 化学 分离(统计) 色谱法 计算生物学 纳米技术 生物化学 材料科学 生物 机器学习 工程类 植物 高效液相色谱法
作者
Caleb Acquah,Yi Wei Chan,Sharadwata Pan,Dominic Agyei,Chibuike C. Udenigwe
出处
期刊:Journal of Food Biochemistry [Wiley]
卷期号:43 (1): e12765-e12765 被引量:45
标识
DOI:10.1111/jfbc.12765
摘要

The application of proteomic and peptidomic technologies for food-derived bioactive peptides is an emerging field in food sciences. These technologies include the use of separation tools coupled to a high-resolution spectrometric and bioinformatic tools for prediction, identification, sequencing, and characterization of peptides. To a large extent, one-dimensional separation technologies have been extensively used as a continuous tool under different optimized conditions for the identification and analysis of food peptides. However, most one-dimensional separation technologies are fraught with significant bottlenecks such as insufficient sensitivity and specificity limits for complex samples. To address this limitation, separation systems based on orthogonal, multidimensional principles, which allow for the coupling of more than one analytical separation tool with different operational principles, provide a higher separation power than one-dimensional separation tools. This review describes the structure-informed separation and purification of protein hydrolyzates to obtain peptides with desirable bioactivities. Practical applications Application of bioactive peptides in the formulation of functional foods, nutraceuticals, and therapeutic agents have increasingly gained scholarly and industrial attention. The bioactive peptides exist originally in protein sources and are only active after hydrolysis of the parent protein. Currently, several tools can be configured in one-dimensional or multidimensional systems for the separation and purification of protein hydrolyzates. The separations are informed by the structural properties such as the molecular weight, charge, hydrophobicity or hydrophilicity, and the solubility of peptides. This review provides a concise discussion on the commonly used analytical tools, their configurations, advantages and challenges in peptide separation. Emphasis is placed on how the structural properties of peptides assist in the separation and purification processes and the concomitant effect of the separation on peptide bioactivity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
欧阳彬欣发布了新的文献求助30
1秒前
Hello应助en采纳,获得30
1秒前
1秒前
感动羊青完成签到,获得积分20
2秒前
2秒前
夏来发布了新的文献求助10
2秒前
烂漫夜梅发布了新的文献求助10
2秒前
李健的小迷弟应助好纠结采纳,获得10
2秒前
poshink发布了新的文献求助10
3秒前
心海发布了新的文献求助10
3秒前
single发布了新的文献求助10
5秒前
薰硝壤应助科研小白采纳,获得20
6秒前
6秒前
zz完成签到,获得积分20
7秒前
黄伊若完成签到 ,获得积分10
7秒前
8秒前
9秒前
10秒前
慕青应助自由的笑容采纳,获得10
10秒前
10秒前
Jeffery完成签到,获得积分10
11秒前
11发布了新的文献求助10
11秒前
11秒前
科研通AI2S应助聪慧百合采纳,获得10
12秒前
12秒前
研友_ED5GK发布了新的文献求助20
13秒前
13秒前
13秒前
13秒前
14秒前
single发布了新的文献求助10
14秒前
14秒前
马路完成签到 ,获得积分10
15秒前
阳光过客发布了新的文献求助10
16秒前
甜甜玫瑰发布了新的文献求助10
16秒前
篇篇高分发布了新的文献求助10
16秒前
思源应助要吐了采纳,获得10
16秒前
烟花应助Fancy采纳,获得10
16秒前
17秒前
玩命做科研完成签到,获得积分10
17秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
A new approach of magnetic circular dichroism to the electronic state analysis of intact photosynthetic pigments 500
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3148940
求助须知:如何正确求助?哪些是违规求助? 2800005
关于积分的说明 7837927
捐赠科研通 2457512
什么是DOI,文献DOI怎么找? 1307891
科研通“疑难数据库(出版商)”最低求助积分说明 628322
版权声明 601685