芳构化
串联
化学
催化作用
全合成
组合化学
有机化学
材料科学
复合材料
作者
Bo Zheng,Hui-Ya Qu,Tian‐Zhuo Meng,Xia Lü,Jie Zheng,Yun‐Gang He,Qi-Qi Fan,Xiao‐Xin Shi
出处
期刊:RSC Advances
[Royal Society of Chemistry]
日期:2018-01-01
卷期号:8 (51): 28997-29007
被引量:11
摘要
Novel total syntheses of oxoaporphine alkaloids such as liriodenine, dicentrinone, cassameridine, lysicamine, oxoglaucine and O-methylmoschatoline were developed. The key step of these total syntheses is Cu-catalyzed conversion of 1-benzyl-3,4-dihydro-isoquinolines (1-Bn-DHIQs) to 1-benzoyl-isoquinolines (1-Bz-IQs) via tandem oxidation/aromatization. This novel Cu-catalyzed conversion has been studied in detail, and was successfully used for constructing the 1-Bz-IQ core.
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