医学
叶黄素
吉西他滨
伊立替康
胰腺癌
奥沙利铂
临床研究阶段
危险系数
内科学
中期分析
肿瘤科
临床终点
胃肠病学
化疗
泌尿科
外科
癌症
随机对照试验
置信区间
结直肠癌
作者
Ramesh K. Ramanathan,Shannon McDonough,Philip A. Philip,Sunil R. Hingorani,Jill Lacy,Jeremy Kortmansky,Jaykumar Thumar,E. Gabriela Chiorean,Anthony F. Shields,Deepti Behl,Paul Mehan,Rakesh Gaur,Tara Elisabeth Seery,Katherine A. Guthrie,Howard S. Hochster
摘要
Pegylated recombinant human hyaluronidase (PEGPH20) degrades hyaluronan (HA) and, in combination with chemotherapy, prolongs survival in preclinical models. The activity of PEGPH20 with modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) was evaluated in patients with metastatic pancreatic cancer (mPC).
科研通智能强力驱动
Strongly Powered by AbleSci AI