微球
材料科学
介孔材料
化学工程
纳米技术
催化作用
有机化学
工程类
化学
作者
Wenqian Xiao,Jing Zhang,Kejiang Li,Xinyu Zou,Yudong Cai,Bo Li,Xue Liu,Liao Xiao-ling
出处
期刊:Journal of Inorganic Materials
[Shanghai Institute of Ceramics]
日期:2019-01-01
卷期号:: 3-3
被引量:1
摘要
Due to the fact that the conventional bioceramic microspheres lack target function, novel litchi-like porous microspheres composed of a core of CaCO 3 and a tunable magnetic-hydroxyapatite (HA) shell were successfully prepared in this study.Antitumor drug, doxorubicin (DOX), was effectively loaded on the HA microspheres which possess magnetic targeting function.In addition, the HA shell, which had favorable biocompatibility and pH response characteristics, could be used to control release of loaded DOX from the litchi-like superparamagnetic microspheres in a simulated acidic tumor cell environment, effectively killing tumor cells and reducing toxic side effects to normal cells.The smart design presented in this study, which incorporates a tunable superparamagnetic shell and a controlled architecture, allows the sensitive release of drugs for efficient antitumor activity.
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