亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Transition from metabolic healthy to unhealthy phenotypes and association with cardiovascular disease risk across BMI categories in 90 257 women (the Nurses' Health Study): 30 year follow-up from a prospective cohort study

医学 疾病 护士健康研究 心血管健康 体质指数 联想(心理学) 内科学 队列 队列研究 梅德林 老年学 前瞻性队列研究 政治学 认识论 哲学 法学
作者
Nathalie Eckel,Yanping Li,Olga Kuxhaus,Norbert Stefan,Frank B. Hu,Matthias B. Schulze
出处
期刊:The Lancet Diabetes & Endocrinology [Elsevier BV]
卷期号:6 (9): 714-724 被引量:369
标识
DOI:10.1016/s2213-8587(18)30137-2
摘要

Background Cardiovascular disease risk among individuals across different categories of BMI might depend on their metabolic health. It remains unclear to what extent metabolic health status changes over time and whether this affects cardiovascular disease risk. In this study, we aimed to examine the association between metabolic health and its change over time and cardiovascular disease risk across BMI categories. Methods Between June and December, 1976, 121 701 female nurses were recruited to the Nurses' Health Study (NHS) of whom 103 298 returned a questionnaire in 1980 used as baseline in this study. After excluding women with a history of cardiovascular disease or cancer, with missing body weight and with underweight. 90 257 women were followed-up from 1980 to 2010 for incident cardiovascular disease. Participants were cross-classified by BMI categories, metabolic health (defined by absence of diabetes, hypertension and hypercholesterolaemia), and change in metabolic health status during follow-up. The cardiovascular component of the NHS is registered with ClinicalTrials.gov, number NCT00005152. Findings During 2 127 391 person-years of follow-up with a median follow-up of 24 years, we documented 6306 cases of cardiovascular disease including 3304 myocardial infarction cases and 3080 strokes. Cardiovascular disease risk of women with metabolically healthy obesity was increased compared with women with metabolically healthy normal weight (HR 1·39, 95% CI 1·15–1·68), but risk was considerably higher in women with metabolically unhealthy normal weight (2·43, 2·19–2·68), overweight (2·61, 2·36–2·89) and obesity (3·15, 2·83–3·50). The majority of metabolically healthy women converted to unhealthy phenotypes (2555 [84%] of 3027 women with obesity, 22 215 [68%] of 32 882 women with normal-weight after 20 years). Women who maintained metabolically healthy obesity during follow-up were still at a higher cardiovascular disease risk compared with women with stable healthy normal weight (HR 1·57, 1·03–2·38), yet this risk was lower than for initially metabolically healthy women who converted to an unhealthy phenotype (normal-weight 1·90, 1·66–2·17 vs obesity 2·74, 2·30–3·27). Particularly incident diabetes and hypertension increased the risk among women with initial metabolic health. Interpretation Even when metabolic health is maintained during long periods of time, obesity remains a risk factor for cardiovascular disease. However, risks are highest for metabolically unhealthy women across all BMI categories. A large proportion of metabolically healthy women converted to an unhealthy phenotype over time across all BMI categories, which is associated with an increased cardiovascular disease risk. Funding US National Institutes of Health, German Federal Ministry of Education and Research.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Liiiiiiiiii发布了新的文献求助10
1秒前
XuchaoD完成签到,获得积分10
9秒前
9秒前
今后应助Liiiiiiiiii采纳,获得10
12秒前
顾矜应助科研通管家采纳,获得10
15秒前
Akim应助科研通管家采纳,获得10
15秒前
19秒前
39秒前
49秒前
1分钟前
小张完成签到 ,获得积分10
1分钟前
可耐的冰萍完成签到,获得积分10
1分钟前
充电宝应助干净涵梅采纳,获得10
1分钟前
1分钟前
1分钟前
1分钟前
1分钟前
李李发布了新的文献求助10
1分钟前
科研通AI5应助李李采纳,获得10
1分钟前
爱笑的毛衣完成签到,获得积分10
1分钟前
太叔丹翠完成签到 ,获得积分10
1分钟前
沉默白猫完成签到 ,获得积分10
1分钟前
2分钟前
sowhat完成签到 ,获得积分10
2分钟前
孙老师完成签到 ,获得积分10
2分钟前
盛事不朽完成签到 ,获得积分10
2分钟前
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
FashionBoy应助科研通管家采纳,获得10
2分钟前
羞涩的傲菡完成签到,获得积分10
2分钟前
2分钟前
Hung发布了新的文献求助10
2分钟前
2分钟前
Lyncon完成签到,获得积分10
2分钟前
Milton_z完成签到 ,获得积分0
2分钟前
Hung完成签到,获得积分10
2分钟前
tingyeh完成签到,获得积分10
3分钟前
3分钟前
两个我完成签到 ,获得积分10
3分钟前
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990049
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256354
捐赠科研通 3270976
什么是DOI,文献DOI怎么找? 1805166
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228