群体猝灭
生物膜
紫红色杆菌
群体感应
鲍曼不动杆菌
微生物学
绿脓素
化学
熊果酸
生物化学
生物
立体化学
细菌
铜绿假单胞菌
植物
遗传学
作者
Sudipta Paul Bhattacharya,Aparna Mitra,Arijit Bhattacharya,Asim K. Sen
出处
期刊:Biofouling
[Informa]
日期:2020-09-13
卷期号:36 (8): 922-937
被引量:21
标识
DOI:10.1080/08927014.2020.1831480
摘要
The quorum quenching (QQ) potential of three pentacyclic triterpenoids, glycyrrhetinic acid (GRA), ursolic acid (UA) and betulinic acid (BA), representing distinct groups of compounds, was evaluated. Violacein production by Chromobacterium violaceum and pyocyanin production by Pseudomonas aeruginosa were severely affected by GRA, UA and BA, suggesting a perturbation of N-acyl homoserine lactone (ASL) based signaling. Molecular docking analysis revealed a possible interaction between ASL-synthase and ASL-dependent transcriptional activator homologs from P. aeruginosa and Acinetobacter baumannii with common binding pockets for GRA, UA and BA. The triterpenoids inhibited biofilm formation by A. baumannii and affected the overall structure of biofilms. When administered in combination, two of the three molecules fostered antibiotic action against A. baumannii biofilms, widening the scope for developing novel combinations against the pathogen.
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