Effect of Xihuang Pill on microcirculation in DMBA combined estrogen and progesterone induced breast precancerous lesions rats

Abstract Objective: To observe the effect of Xihuang Pill on microcirculation in 7,12-dimethylbenzoanthracene (DMBA) combined estrogen and progesterone induced breast precancerous lesions rats. Method: DMBA combined estrogen and progesterone were used to establish the model of breast precancerous lesions for 10 weeks in SD rats, then the low, medium and high dose Xihuang Pill (0.27, 0.55, 1.37g·kg −1 ) was given intragastric administration, and tamoxifen (4 mg·kg −1 ) was given intragastric administration as a positive control after the breast precancerous lesions models established successfully. The breast microcirculation was measured by laser Doppler flowmetry (LDF) in rats after 4 weeks of Xihuang Pill and tamoxifen intragastric administration. Result: Compared with the normal control group, the microcirculation perfusion of breast in the disease model group decreased significantly ( P < 0.05). Compared with the disease model group, the breast microcirculation perfusion in each dose group of Xihuang Pill increased significantly ( P < 0.05). Conclusion: The mechanism of Xihuang Pill in the treatment of breast precancerous lesions may be related to the improvement of breast microcirculation.