医学
动脉导管
胎龄
心脏病学
内科学
预测值
平均血小板体积
血小板
接收机工作特性
腺苷
血小板聚集
前瞻性队列研究
怀孕
遗传学
生物
作者
Yunyun Ren,Xiangyu Gao,H Y Wang,Bo Yang,Dandan Zhao,Di Huang,Min‐Ying Su,Liantao Li
出处
期刊:Chinese journal of pediatrics
日期:2021-02-02
卷期号:59 (2): 113-118
标识
DOI:10.3760/cma.j.cn112140-20200818-00807
摘要
Objective: To explore the predictive value of platelet aggregation rate in patent ductus arteriosus in preterm infants. Methods: This prospective nested case-control study enrolled 72 preterm infants with gestational age 0.05). The low platelet aggregation rate induced by adenosine diphosphate and low thrombocytocrit were independent risk factors for hsPDA in preterm infants (OR=4.525 and 3.994, 95%CI: 1.305-15.689 and 1.143-13.958, respectively). And the adenosine diphosphate-induced platelet aggregation rate had moderate predictive value for hsPDA in preterm infants, as the area under the receiver operating characteristic curve was 0.809, and the cutoff value was 0.245 with 0.67 sensitivity and 0.86 specificity. Conclusions: Poor platelet aggregation function and low thrombocytocrit are independent risk factors for hsPDA in preterm infants with gestational age<32 weeks. Low platelet aggregation rate induced by adenosine diphosphate has moderate predictive value for hsPDA patency.
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