阳离子聚合
基因传递
阳离子脂质体
核酸
遗传增强
背景(考古学)
脂质体
生物相容性材料
纳米技术
计算生物学
化学
生物
基因
生物化学
医学
材料科学
生物医学工程
古生物学
有机化学
作者
Hélder Ferreira Teixeira,Fernanda Bruxel,Michelle Fraga,Roselena Silvestri Schuh,Giovanni K. Zorzi,Úrsula Matte,Elias Fattal
标识
DOI:10.1016/j.ijpharm.2017.10.030
摘要
Since the first clinical studies, knowledge in the field of gene therapy has advanced significantly, and these advances led to the development and subsequent approval of the first gene medicines. Although viral vectors-based products offer efficient gene expression, problems related to their safety and immune response have limited their clinical use. Thus, design and optimization of nonviral vectors is presented as a promising strategy in this scenario. Nonviral systems are nanotechnology-based products composed of polymers or lipids, which are usually biodegradable and biocompatible. Cationic liposomes are the most studied nonviral carriers and knowledge about these systems has greatly evolved, especially in understanding the role of phospholipids and cationic lipids. However, the search for efficient delivery systems aiming at gene therapy remains a challenge. In this context, cationic nanoemulsions have proved to be an interesting approach, as their ability to protect and efficiently deliver nucleic acids for diverse therapeutic applications has been demonstrated. This review focused on cationic nanoemulsions designed for gene therapy, providing an overview on their composition, physicochemical properties, and their efficacy on biological response in vitro and in vivo.
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