Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram

右美托咪定 异丙酚 无意识 医学 麻醉 脑电图 麻醉剂 药理学 药品 镇静 精神科
作者
A Scheinin,Roosa Kallionpää,Duan Li,Minna Kallioinen,Kaike Kaisti,Jaakko Långsjö,Anu Maksimow,Tero Vahlberg,Katja Valli,George A. Mashour,Antti Revonsuo,Harry Scheinin
出处
期刊:Anesthesiology [Lippincott Williams & Wilkins]
卷期号:129 (1): 22-36 被引量:54
标识
DOI:10.1097/aln.0000000000002192
摘要

Differentiating drug-related changes and state-related changes on the electroencephalogram during anesthetic-induced unconsciousness has remained a challenge. To distinguish these, we designed a rigorous experimental protocol with two drugs known to have distinct molecular mechanisms of action. We hypothesized that drug- and state-related changes can be separated.Forty-seven healthy participants were randomized to receive dexmedetomidine (n = 23) or propofol (n = 24) as target-controlled infusions until loss of responsiveness. Then, an attempt was made to arouse the participant to regain responsiveness while keeping the drug infusion constant. Finally, the concentration was increased 1.5-fold to achieve presumable loss of consciousness. We conducted statistical comparisons between the drugs and different states of consciousness for spectral bandwidths, and observed how drug-induced electroencephalogram patterns reversed upon awakening. Cross-frequency coupling was also analyzed between slow-wave phase and alpha power.Eighteen (78%) and 10 (42%) subjects were arousable during the constant drug infusion in the dexmedetomidine and propofol groups, respectively (P = 0.011 between the drugs). Corresponding with deepening anesthetic level, slow-wave power increased, and a state-dependent alpha anteriorization was detected with both drugs, especially with propofol. The slow-wave and frontal alpha activities were momentarily disrupted as the subjects regained responsiveness at awakening. Negative phase-amplitude coupling before and during loss of responsiveness frontally and positive coupling during the highest drug concentration posteriorly were observed in the propofol but not in the dexmedetomidine group.Electroencephalogram effects of dexmedetomidine and propofol are strongly drug- and state-dependent. Changes in slow-wave and alpha activity seemed to best detect different states of consciousness.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
绵绵球发布了新的文献求助100
刚刚
刚刚
世界上最后一只呜呜怪完成签到,获得积分10
刚刚
cc2713206完成签到,获得积分0
1秒前
九月发布了新的文献求助10
1秒前
1秒前
Jasper应助北城采纳,获得10
3秒前
A阿澍发布了新的文献求助10
3秒前
顺利煎蛋完成签到,获得积分10
3秒前
肖肖发布了新的文献求助10
4秒前
chengmin完成签到 ,获得积分10
4秒前
wei发布了新的文献求助50
4秒前
5秒前
6秒前
sunwen发布了新的文献求助10
6秒前
7秒前
8秒前
北城完成签到,获得积分10
9秒前
十三完成签到 ,获得积分10
10秒前
打打应助傲寒采纳,获得10
10秒前
小李吃小孩完成签到,获得积分10
10秒前
含蓄大雁完成签到,获得积分10
10秒前
11秒前
Livrik发布了新的文献求助10
12秒前
卢敏明发布了新的文献求助10
12秒前
李健应助俏皮的白柏采纳,获得10
13秒前
13秒前
很好关注了科研通微信公众号
14秒前
14秒前
15秒前
研友_VZG7GZ应助九月采纳,获得10
16秒前
TTm关注了科研通微信公众号
16秒前
17秒前
17秒前
顾矜应助lixiaolu采纳,获得10
18秒前
liu发布了新的文献求助10
18秒前
19秒前
Orange应助光亮嵩采纳,获得10
19秒前
20秒前
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035