诱导多能干细胞
重编程
心肌细胞
生物
胚胎干细胞
表观遗传学
干细胞
药物发现
细胞生物学
细胞分化
神经科学
遗传学
细胞
生物信息学
基因
作者
Yoshinori Yoshida,Shinya Yamanaka
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2017-06-09
卷期号:120 (12): 1958-1968
被引量:201
标识
DOI:10.1161/circresaha.117.311080
摘要
Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to embryonic stem cells, such as the capacity of self-renewal and differentiation into many types of cells, including cardiac myocytes. Although initially the reprogramming efficiency was low, several improvements in reprogramming methods have achieved robust and efficient generation of iPSCs without genomic insertion of transgenes. iPSCs display clonal variations in epigenetic and genomic profiles and cellular behavior in differentiation. iPSC-derived cardiac myocytes (iPSC cardiac myocytes) recapitulate phenotypic differences caused by genetic variations, making them attractive human disease models, and are useful for drug discovery and toxicology testing. In addition, iPSC cardiac myocytes can help with patient stratification in regard to drug responsiveness. Furthermore, they can be used as source cells for cardiac regeneration in animal models. Here, we review recent progress in iPSC technology and its applications to cardiac diseases.
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