Poly(Lactic Acid) Block Copolymers with Poly(Hexylene Succinate) as Microparticles for Long-Acting Injectables of Risperidone Drug

差示扫描量热法 共聚物 傅里叶变换红外光谱 材料科学 核化学 扫描电子显微镜 生物相容性 高分子化学 微粒 聚合物 化学工程 化学 复合材料 工程类 冶金 物理 热力学
作者
Iouliana Chrysafi,Stavroula Nanaki,Alexandra Zamboulis,Margaritis Kostoglou,E. Pavlidou,Dimitrios Ν. Bikiaris
出处
期刊:Polymers [Multidisciplinary Digital Publishing Institute]
卷期号:14 (19): 4111-4111 被引量:3
标识
DOI:10.3390/polym14194111
摘要

In the present work, Risperidone microparticles from poly(lactic acid)/poly(hexylene succinate) (PLA-b-PHSu) block copolymers in different ratios, 95/05, 90/10 and 80/20 w/w, were examined as long-acting injectable formulations. Nuclear magnetic resonance (NMR) was used to verify the successful synthesis of copolymers. Enzymatic hydrolysis showed an increase in weight loss as the content of PHSu increased, while the cytotoxicity studies confirmed the biocompatibility of the copolymers. The polyesters were further used to encapsulate Risperidone by spray drying. The drug-loaded microparticles were studied by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD). SEM microphotographs confirmed that spherically shaped microparticles were prepared with sizes about 5-12 μm, while XRD and differential scanning calorimetry (DSC) studies evidenced that Risperidone was encapsulated in amorphous form. The drug loading and the entrapment efficiency of Risperidone were studied as well as the in vitro release from the prepared microparticles. As the content of PHSu increased, a higher release of Risperidone was observed, with PLA-b-PHSu 80/20 w/w succeeding to release 100% of RIS within 12 days. According to theoretical modeling, the kinetics of RIS release from PLA-b-PHSu microparticles is complex, governed by both diffusion and polymer erosion.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
1秒前
2秒前
烟花应助研友_Zl1Jz8采纳,获得30
2秒前
3秒前
王登刚完成签到,获得积分10
3秒前
梁小氓发布了新的文献求助10
3秒前
天涯发布了新的文献求助10
4秒前
量子星尘发布了新的文献求助10
4秒前
薛妖怪完成签到,获得积分10
5秒前
5秒前
5秒前
zhen9203发布了新的文献求助10
6秒前
小二郎应助落去归来采纳,获得10
6秒前
深情安青应助zwl111采纳,获得10
6秒前
猪猪hero应助SHD采纳,获得10
6秒前
6秒前
赘婿应助寒冷的咖啡采纳,获得10
7秒前
风吹不到海湾完成签到,获得积分10
7秒前
7秒前
8秒前
Chambray发布了新的文献求助10
8秒前
顾矜应助赵立双采纳,获得10
8秒前
8秒前
9秒前
飞翔的梦完成签到,获得积分10
10秒前
Stevielau完成签到,获得积分10
10秒前
轩1完成签到,获得积分20
10秒前
小九完成签到 ,获得积分10
10秒前
11秒前
11秒前
Luna应助黑面包采纳,获得10
11秒前
WWW=WWW发布了新的文献求助10
12秒前
隐形曼青应助lff采纳,获得10
12秒前
CG发布了新的文献求助10
12秒前
搜集达人应助热情的戾采纳,获得10
13秒前
彳亍发布了新的文献求助10
13秒前
爆米花应助默默的巧荷采纳,获得10
13秒前
丘比特应助北落采纳,获得10
13秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3978526
求助须知:如何正确求助?哪些是违规求助? 3522634
关于积分的说明 11214133
捐赠科研通 3260065
什么是DOI,文献DOI怎么找? 1799744
邀请新用户注册赠送积分活动 878642
科研通“疑难数据库(出版商)”最低求助积分说明 807002