幽闭
脱离理论
扣带回前部
心理学
神经科学
任务(项目管理)
人口
睡眠(系统调用)
认知
医学
环境卫生
操作系统
经济
老年学
管理
计算机科学
核心
作者
Gal Atlan,Noa Matosevich,Noa Peretz‐Rivlin,Idit Marsh‐Yvgi,Noam Zelinger,Eden Chen,Timna Kleinman,Noa Bleistein,Efrat Sheinbach,Maya Groysman,Yuval Nir,Ami Citri
标识
DOI:10.1038/s41467-024-48829-6
摘要
Abstract The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness to stimuli, which spans the axis of engagement. To test this hypothesis, we recorded claustrum population dynamics from male mice during both sleep and an attentional task (‘ENGAGE’). Heightened activity in claustrum neurons projecting to the anterior cingulate cortex (ACCp) corresponded to reduced sensory responsiveness during sleep. Similarly, in the ENGAGE task, heightened ACCp activity correlated with disengagement and behavioral lapses, while low ACCp activity correlated with hyper-engagement and impulsive errors. Chemogenetic elevation of ACCp activity reduced both awakenings during sleep and impulsive errors in the ENGAGE task. Furthermore, mice employing an exploration strategy in the task showed a stronger correlation between ACCp activity and performance compared to mice employing an exploitation strategy which reduced task complexity. Our results implicate ACCp claustrum neurons in restricting engagement during sleep and goal-directed behavior.
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