立体中心
化学
立体选择性
立体化学
对映选择合成
药物化学
有机化学
催化作用
作者
Nuermaimaiti Yisimayili,Chong‐Dao Lu
标识
DOI:10.1021/acs.joc.4c01235
摘要
-Sulfinyl metalloenamines, derived from geometry-defined β,β-disubstituted enesulfinamides, undergo conjugate addition-elimination reaction with β-tosyl nitroolefin to afford α-sulfonylvinylated ketimines with high stereocontrol. Further desulfonylation using sodium naphthalenide gives carbonyl surrogates bearing a less-accessible acyclic quaternary α-stereocenters substituted with an ethenyl group and two sterically and electronically similar groups (e.g., methyl and ethyl). Synthetic application of the described protocol was demonstrated by enantioselective synthesis of (
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