Electrospinning of bovine serum albumin‐based nano‐fibers: From synthesis to medical prospects; Challenges and future directions

Bovine serum albumin (BSA) is a globular non-glycoprotein that has gotten a lot of attention because of its unique properties like biocompatibility, biodegradability, non-immunogenicity, non-toxicity, and strong resemblance to the natural extracellular matrix (ECM). Given its robust mechanical properties, such as interfacial tension, conductivity, swelling resistance, and viscoelasticity, it can be concluded that it is an appropriate matrix for producing novel BSA-based nanoconstructs. Thus, simple analytic methods are required for accurately detecting BSA as a model protein in medical sciences and healthcare. Furthermore, the characteristics mentioned above aid BSA in the electrospinning process, which results in fibers conjugated with other polymers. Electrospun synthesis has recently received much attention for its ability to produce stable, biomimicking, highly porous, 3D BSA-derived nano-fibers. As a result, BSA-based nano-fibers have achieved exclusive developments in the medical sector, such as tissue engineering for the remodeling of damaged tissue or organ repair by creating artificial ones. Meanwhile, they could be used as drug delivery systems (DDS) for target-specific drug delivery, wound dressings, and so on. This study illustrates the structural and physicochemical properties of BSA and the determination of BSA using various methods, by citing recent reports and current developments in the medical field. Furthermore, current challenges and future directions are also highlighted.