Spiky Artificial Peroxidases with V−O−Fe Pair Sites for Combating Antibiotic‐Resistant Pathogens

Abstract With the sharp rise of antibiotic‐resistant pathogens worldwide, it is of enormous importance to create new strategies for combating pathogenic bacteria. Here, we create an iron oxide‐based spiky artificial peroxidase (POD) with V−O−Fe pair sites (V‐Fe 2 O 3 ) for combating methicillin‐resistant Staphylococcus aureus (MRSA). The experimental studies and theoretical calculations demonstrate that the V‐Fe 2 O 3 can achieve the localized “capture and killing” bifunction from the spiky morphology and massive reactive oxygen species (ROS) production. The V‐Fe 2 O 3 can reach nearly 100 % bacterial inhibition over a long period by efficiently oxidizing the lipid membrane. Our wound disinfection results identify that the V‐Fe 2 O 3 can not only efficiently eliminate MRSA and their biofilm but also accelerate wound recovery without causing noticeable inflammation and toxicity. This work offers essential insights into the critical roles of V−O−Fe pair sites and localized “capture and killing” in biocatalytic disinfection and provides a promising pathway for the de novo design of efficient artificial peroxidases.