自愈水凝胶
纳米复合材料
聚丙烯酰胺
海藻酸钠
材料科学
化学工程
纳米颗粒
复合数
聚合物
钠
组织工程
胶束
化学
复合材料
高分子化学
水溶液
纳米技术
生物医学工程
有机化学
工程类
冶金
医学
作者
Shiyuan Liu,Yang Si,Yanni Tan,Xiangyan Liu,Yingtao Tian,Luxin Liang,Hong Wu
出处
期刊:Biomaterials advances
日期:2022-09-15
卷期号:141: 213123-213123
被引量:6
标识
DOI:10.1016/j.bioadv.2022.213123
摘要
Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering. However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications. In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites was developed by the sol-gel method. The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point. The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels. Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate. In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells. In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag2O content.
科研通智能强力驱动
Strongly Powered by AbleSci AI