Risk of Cardiovascular Death in Osteosarcoma

骨肉瘤 医学 流行病学 内科学 化疗 骨科手术 放射治疗 癌症 肿瘤科 外科 病理
作者
Yi Jia,Yan Xiong,Ping Zhan,Guangye Wang
出处
期刊:JCPSP. Journal of the College of Physicians & Surgeons Pakistan [College of Physicians and Surgeons Pakistan]
卷期号:33 (3): 266-269 被引量:1
标识
DOI:10.29271/jcpsp.2023.03.266
摘要

To assess the risk of cardiovascular mortality (CVM) in patients with osteosarcoma.Descriptive study. Place and Duration of the Study: Department of Orthopaedics, The People's Hospital of Baoan, Shenzhen, Guangdong, China, from 1st January 2019 to 1st January 2022.Data on patients diagnosed with osteosarcoma, between 1975 and 2019, were obtained from the surveillance, epidemiology, and end results (SEER) database. Using the Nelson-Aalen cumulative risk curve to assess the risk of CVM in patients with osteosarcoma. Competing risk models were used for identifying and analysing independent risk factors for CVM in the patients.Data from a total of 1335 patients with osteosarcoma were obtained from the SEER database. The characteristics of patients with osteosarcoma independently related with a high risk of CVM were age over 65 years (HR: 2.528; 95% CI: 1.156 - 5.527), race of other categories (HR: 1.498; 95% CI: 1.044 - 2.151), and exposure radiotherapy (HR: 0.493; 95% CI: 0.244 - 0.998). Receiving chemotherapy was independently associated with a low risk of CVM (HR: 1.911; 95% CI: 1.016 - 3.593).Cardiovascular disease death from osteosarcoma was significantly associated with older age at diagnosis, race other class, receiving radiation therapy, and not undergoing chemotherapy.Osteosarcoma, Cancer risk factors, Epidemiology.

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