Long-term exposure to particulate matter and COPD mortality: Insights from causal inference methods based on a large population cohort in southern China

慢性阻塞性肺病 医学 危险系数 混淆 队列 比例危险模型 队列研究 置信区间 因果推理 前瞻性队列研究 人口 边际结构模型 人口学 微粒 环境卫生 内科学 生物 病理 社会学 生态学
作者
Ying Wang,Zhicheng Du,Yuqin Zhang,Shirui Chen,Shao Lin,Philip K. Hopke,David Q. Rich,Kai Zhang,Xiaobo Xue Romeiko,Xin Deng,Yanji Qu,Yu Liu,Ziqiang Lin,Shuming Zhu,Wangjian Zhang,Yuantao Hao
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:863: 160808-160808 被引量:18
标识
DOI:10.1016/j.scitotenv.2022.160808
摘要

Evidence of the association between long-term exposure to particulate matter (PM) and chronic obstructive pulmonary disease (COPD) mortality from large population-based cohort study is limited and often suffers from residual confounding issues with traditional statistical methods. We hereby assessed the casual relationship between long-term PM (PM2.5, PM10 and PM10-2.5) exposure and COPD mortality in a large cohort of Chinese adults using state-of-the-art causal inference approaches.A total of 580,757 participants in southern China were enrolled in a prospective cohort study from 2009 to 2015 and followed up until December 2020. Exposures to PM at each residential address were obtained from the Long-term Gap-free High-resolution Air Pollutant Concentration dataset. Marginal structural Cox models were used to investigate the association between COPD mortality and annual average exposure levels of PM exposure.During an average follow-up of 8.0 years, 2250 COPD-related deaths occurred. Under a set of causal inference assumptions, the hazard ratio (HR) for COPD mortality was estimated to be 1.046 (95 % confidence interval: 1.034-1057), 1.037 (1.028-1.047), and 1.032 (1.006-1.058) for each 1-μg/m3 increase in annual average concentrations of PM2.5, PM10, and PM10-2.5 respectively. Additionally, the detrimental effects appeared to be more pronounced among the elderly (age ≥ 65) and inactive participants. The effect estimates of PM2.5, PM10, and PM10-2.5 tend to be greater among participants who were generally exposed to PM10 concentrations below 70 μg/m3 than that among the general population.Our results support causal links between long-term PM exposure and COPD mortality, highlighting the urgency for more effective strategies to reduce PM exposure, with particular attention on protecting potentially vulnerable groups.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
英吉利25发布了新的文献求助10
1秒前
星辰大海应助WB采纳,获得10
1秒前
花开富贵完成签到,获得积分10
1秒前
1秒前
1秒前
852应助凉雨街采纳,获得10
2秒前
樱桃味的火苗完成签到,获得积分10
2秒前
许晴发布了新的文献求助10
2秒前
8R60d8应助爱笑的雪糕采纳,获得10
3秒前
3秒前
3秒前
所所应助bixun采纳,获得10
3秒前
李爱国应助ppapp采纳,获得10
3秒前
飞鸿影下完成签到 ,获得积分10
4秒前
勤恳的一斩完成签到,获得积分10
4秒前
豆豆完成签到,获得积分10
4秒前
4秒前
dongdongqiang完成签到,获得积分10
5秒前
鹤雪完成签到,获得积分20
5秒前
阿北完成签到,获得积分10
5秒前
6秒前
简柠完成签到,获得积分10
6秒前
6秒前
6秒前
情怀应助单身的世倌采纳,获得10
6秒前
6秒前
咕噜咕噜完成签到 ,获得积分10
6秒前
大方念云完成签到,获得积分10
7秒前
笨笨的仙人掌完成签到,获得积分10
7秒前
Hellowa完成签到,获得积分10
7秒前
ferritin发布了新的文献求助30
7秒前
ffw1完成签到,获得积分10
7秒前
7秒前
乔苏惠娜完成签到,获得积分10
7秒前
7秒前
Yyy完成签到,获得积分10
7秒前
鸭梨完成签到,获得积分10
8秒前
打打应助安详蜜蜂采纳,获得10
8秒前
8秒前
xinyuY完成签到,获得积分10
8秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
网络安全 SEMI 标准 ( SEMI E187, SEMI E188 and SEMI E191.) 1000
计划经济时代的工厂管理与工人状况(1949-1966)——以郑州市国营工厂为例 500
INQUIRY-BASED PEDAGOGY TO SUPPORT STEM LEARNING AND 21ST CENTURY SKILLS: PREPARING NEW TEACHERS TO IMPLEMENT PROJECT AND PROBLEM-BASED LEARNING 500
Why America Can't Retrench (And How it Might) 400
Two New β-Class Milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation, Structure Elucidation and Biological Properties 300
Modern Britain, 1750 to the Present (第2版) 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 催化作用 遗传学 冶金 电极 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 4614581
求助须知:如何正确求助?哪些是违规求助? 4018748
关于积分的说明 12439646
捐赠科研通 3701503
什么是DOI,文献DOI怎么找? 2041241
邀请新用户注册赠送积分活动 1073983
科研通“疑难数据库(出版商)”最低求助积分说明 957639