已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Pharmacokinetics of Atorvastatin and Metformin after Coadministration with Islatravir in Healthy Adults

阿托伐他汀 二甲双胍 医学 药代动力学 药理学 血脂异常 药物相互作用 口服 内科学 糖尿病 内分泌学
作者
Jacqueline B. McCrea,Munjal Patel,Yang Liu,Ryan Vargo,Rose Witter,Andrew Litovsky,S. Aubrey Stoch,Marian Iwamoto,Randolph P. Matthews
出处
期刊:The Journal of Clinical Pharmacology [Wiley]
标识
DOI:10.1002/jcph.6169
摘要

Abstract Islatravir, a deoxyadenosine analog that inhibits HIV‐1 replication by multiple mechanisms of action, including reverse transcriptase translocation inhibition, is being developed for use in HIV‐1 treatment. People living with HIV often have comorbidities, such as dyslipidemia or type 2 diabetes mellitus, necessitating long‐term concomitant drug therapy. This nonrandomized, two‐period, fixed‐sequence, open‐label, phase 1, drug‐drug interaction study was conducted to evaluate the effects of islatravir coadministration on atorvastatin and metformin pharmacokinetics (PK) in healthy adults. In period 1, participants received a single dose of atorvastatin 20 mg and metformin 1000 mg. After a 5‐day washout, participants received atorvastatin 20 mg and metformin 1000 mg coadministered with a single oral dose of islatravir 60 mg (period 2). In both periods, blood samples were collected up to 72 h post dose to characterize the plasma PK of atorvastatin and metformin. Safety was monitored throughout the study. Fourteen participants were enrolled and completed the study. Atorvastatin and metformin plasma PK were similar after administration of atorvastatin and metformin with or without islatravir. The geometric mean ratio and 90% confidence interval of the area under the concentration‐time curve from time zero to infinity (AUC 0‐∞ ) for atorvastatin and metformin with or without a single oral dose of islatravir were 1.04 (1.00‐1.10) and 0.87 (0.79‐0.96), respectively. Coadministration of islatravir with atorvastatin and metformin was well tolerated. Overall, coadministration of atorvastatin and metformin with a single oral dose of islatravir did not have a clinically meaningful effect on the PK profiles of either drug.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
略略略完成签到,获得积分10
1秒前
Eliauk完成签到 ,获得积分10
2秒前
科目三应助重要的一凡采纳,获得10
3秒前
sobergod完成签到 ,获得积分10
4秒前
Anquan完成签到,获得积分10
6秒前
Akim应助xy采纳,获得10
6秒前
夏惋清完成签到 ,获得积分0
6秒前
miracle完成签到,获得积分10
8秒前
9秒前
10秒前
七七完成签到,获得积分10
10秒前
风中巧曼发布了新的文献求助10
11秒前
一只小锦鲤完成签到 ,获得积分10
12秒前
啊啊啊啊完成签到,获得积分10
15秒前
董湘澜发布了新的文献求助10
15秒前
rita4616发布了新的文献求助10
17秒前
量子星尘发布了新的文献求助10
18秒前
所所应助Jemma采纳,获得10
19秒前
仙乐完成签到,获得积分10
19秒前
lyy完成签到 ,获得积分10
19秒前
23秒前
znlion完成签到,获得积分10
23秒前
充电宝应助欣欣采纳,获得10
24秒前
25秒前
慕青应助shidandan采纳,获得10
25秒前
Layace完成签到 ,获得积分10
25秒前
Joyce完成签到,获得积分10
26秒前
风中巧曼完成签到,获得积分20
27秒前
难过千易发布了新的文献求助10
28秒前
完美世界应助song采纳,获得10
30秒前
共享精神应助song采纳,获得10
30秒前
30秒前
s橙子味日出_完成签到 ,获得积分10
33秒前
33秒前
34秒前
健忘幻儿完成签到 ,获得积分10
34秒前
今后应助科研通管家采纳,获得10
35秒前
JamesPei应助科研通管家采纳,获得10
35秒前
wanci应助科研通管家采纳,获得10
35秒前
35秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976512
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203949
捐赠科研通 3257210
什么是DOI,文献DOI怎么找? 1798648
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806555